If you find signs of infestation, grab your luggage and report what you found to the front desk staff. Ask to be reassigned or simply get a refund and find a different hotel or motel for the night.
If your inspection is negative and you feel comfortable with staying in the room, get out the metal luggage rack and place it away from the wall. Bed bugs cannot crawl up the metal legs of the luggage rack, so your luggage will be safe, in case you missed something.
When you return home, carefully check your luggage and clothing for any signs of live bed bugs. Putting clothing into a clothes drier set on high for 45 minutes will kill all stages of bed bugs, including their eggs.